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Antipsychotic efficacy of evenamide (NW-3509) is due to modulation of glutamatergic dysregulation

This dual mechanism produces more pronounced weight loss in clinical trials compared to semaglutide alone, which could mean greater estrogen reduction through adipose tissue loss

22(1): 4654 Jiang X, Williams KM, Liauw WS, et al

doi: 10.1038/s41538-024-00348-w 188

This suggests that when aiming to enhance ATP production by increasing TCA cycle flux, it is essential to consider the interplay between glycolysis and the TCA cycle, as excessive TCA cycle activity may suppress glycolysis